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目的 比较单用爱迪注射液(Aidi)、CAF(CTX+THP+5-Fu)化疗方案及Aidi加CAF联合化疗方案治疗晚期乳腺癌的疗效。方法 46例晚期乳腺癌随机分成3组,Aidi单药组11例,CAF方案化疗组17例,Aidi加CAF方案联合化疗组18例。结果 Aidi、CAF方案化疗以及Aidi+CAF联合化疗方案治疗组有效率分别为27.2％(3/11)、41.2％(7/17)、50.0％(9/18);CAF方案,主要毒副反应是骨髓抑制,其发生率为64.7％,较其它两组严重(P<0.01)。结论 Aidi+CAF联合方案治疗晚期乳腺癌有增效、减毒作用,可能是治疗晚期乳腺癌较好的方案之一。
Objective To compare the curative effect of Aidi, CAF (CTX + THP + 5-Fu) chemotherapy alone and Aidi plus CAF plus chemotherapy in the treatment of advanced breast cancer. Methods Forty-six patients with advanced breast cancer were randomly divided into three groups: 11 patients in the Aidi monotherapy group, 17 patients in the CAF regimen and 18 patients in the Aidi plus CAF regimen. Results The effective rates of Aidi, CAF regimen and Aidi + CAF regimen were 27.2% (3/11), 41.2% (7/17) and 50.0% (9/18), respectively. The CAF regimen, Is myelosuppression, the incidence was 64.7%, compared with the other two groups (P <0.01). Conclusions Aidi + CAF combination regimen has synergistic and attenuating effects on advanced breast cancer, which may be one of the better regimens for the treatment of advanced breast cancer.