骨保护素(OPG)是由成骨细胞分泌的一种无跨膜结构的可溶性糖蛋白,可影响血管钙化和动脉硬化的过程,是动脉粥样硬化进程及心血管病病死率的独立危险因子。OPG与急性冠状动脉综合征(ACS)具有相关性,在急性心肌梗死和不稳定型心绞痛患者的血清中均发现较高水平的OPG表达。虽然这一特点的具体机制尚不明确,但OPG在ACS临床应用中的价值不可忽视。 Osteoprotegerin (OPG) is a non-transmembrane soluble glycoprotein secreted by osteoblasts that affects the process of vascular calcification and atherosclerosis and is an independent risk factor for atherosclerotic progression and cardiovascular mortality . OPG is associated with acute coronary syndrome (ACS), and higher levels of OPG expression are found in the serum of patients with acute myocardial infarction and unstable angina. Although the specific mechanism of this feature is not clear, but the value of OPG in the clinical application of ACS can not be ignored.