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还原性叶酸载体 (ＲＦＣ)功能下降、甲氨蝶呤 (ＭＴＸ)聚谷氨酸合成减少、二氢叶酸还原酶活性增加是ＭＴＸ耐药的三大主要原因[1] 。ＲＦＣ是转运ＭＴＸ进入细胞使其产生抗肿瘤作用的首要环节[2 6] 。因而检测急性白血病 (ＡＬ)患者的ＲＦＣ功能 ,可部分反映白血病细胞对ＭＴ
Reduced folate carrier (RFC) function decreased, methotrexate (MTX) polyglutamic acid synthesis decreased dihydrofolate reductase activity is the three major causes of MTX resistance [1]. RFC is the first link that transports MTX into cells to produce antitumor effect [26]. Thus the detection of RFC in patients with acute leukemia (AL) may partly reflect the effect of leukemia cells on MT