Syk、c-erbB-2和EGFR在贲门腺癌中的表达及其临床意义

来源 :中国肿瘤生物治疗杂志 | 被引量 : 0次 | 上传用户:chen_gm
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:检测贲门腺癌(gastric cardiac adenocarcinoma,GCA)中抑癌基因脾酪氨酸激酶(spleen tyrosine kinase,Syk)及原癌基因c-erbB-2、表皮生长因子受体(epidermal growth factor receptor,EGFR)的表达情况,探讨其相互关系及其与贲门腺癌发生、发展的关系。方法:收集河北医科大学第四医院胸外科2006年10月至2007年2月手术切除贲门腺癌标本91例,患者术前未经任何抗癌治疗。应用免疫组化SP法检测贲门腺癌组织及相应切缘外正常黏膜组织中Syk、c-erbB-2、EGFR的表达情况,进行相关性比较。结果:Syk在贲门腺癌组织的阳性表达率为24.18%,明显低于相应切缘外正常组织(60.44%,P<0.01)。c-erbB-2、EGFR在贲门腺癌组织的阳性表达率分别为56.04%和58.24%,明显高于其在相应切缘外正常组织中的阳性表达率(20.88%,21.98%;均P<0.01)。Syk及c-erbB-2表达均与肿瘤组织的病理分级、淋巴结转移及TNM分期有明显的相关性(P<0.05或P<0.01)。EGFR表达仅与淋巴结转移相关(P<0.01)。Syk与c-erbB-2和EGFR表达均有相关性(P<0.05),而Syk和EGFR表达两者无明显相关性(P>0.05)。结论:Syk、c-erbB-2、EGFR基因在贲门腺癌中均异常表达,可能与贲门腺癌的发生有关;3种蛋白的联合检测对贲门腺癌的预后评估有一定的指导意义。 Objective: To detect the expression of spleen tyrosine kinase (Syk), c-erbB-2 and epidermal growth factor receptor (VEGF) in gastric cardiac adenocarcinoma (GCA) EGFR) expression, to explore the relationship between them and the occurrence and development of gastric cardia adenocarcinoma. Methods: Totally 91 cases of gastric cardia adenocarcinoma were collected from the Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University from October 2006 to February 2007 without any anti-cancer therapy before operation. The expression of Syk, c-erbB-2 and EGFR in gastric cardia adenocarcinoma tissues and corresponding normal mucosa tissues was detected by immunohistochemical SP method and the correlation was compared. Results: The positive expression rate of Syk in gastric cardia adenocarcinoma was 24.18%, which was significantly lower than that in the corresponding normal tissues (60.44%, P <0.01). The positive rates of c-erbB-2 and EGFR in gastric cardia adenocarcinoma were 56.04% and 58.24%, respectively, which were significantly higher than those in normal tissues (20.88%, 21.98%, P < 0.01). The expressions of Syk and c-erbB-2 were significantly correlated with the histological grade, lymph node metastasis and TNM stage (P <0.05 or P <0.01). EGFR expression was only associated with lymph node metastasis (P <0.01). There was a significant correlation between Syk and c-erbB-2 and EGFR (P <0.05), but there was no significant correlation between Syk and EGFR (P> 0.05). Conclusion: Syk, c-erbB-2 and EGFR genes are all abnormally expressed in gastric cardia adenocarcinoma, which may be related to the occurrence of gastric cardia adenocarcinoma. The combined detection of these three proteins may be helpful for the prognosis evaluation of gastric cardia adenocarcinoma.
其他文献
青少年犯罪的原因是复杂的,受到的消极影响是多方面的。家庭对青少年犯罪的影响,向来被认为是至关重要的,乃至有人将其作为青少年犯罪的首要因素。同样,人们对家庭在预防和矫治青
随着现代信息技术的发展和应用,人们在生产生活和工作学习中都已经深深感受到其影响无处不在,尤其是在教育教学中的应用,更是为教学现代化插上了腾飞的翅膀,深受广大师生的喜
改革开放以来,区域卫生发展的主要障碍是什么?卫生综合效益显示什么特征?新的区域卫生规划战略依据是什么?这些问题都应在兼顾国家、部门、单位和个人利益的前提下通过比较
目的:探讨骆驼蓬总碱(totalalkaloidofHarmaline,TAH)对兔晶状体囊外摘除术(extracapsularlensextraction,ECLE)后后发性白内障形成的影响。方法:在兔ECLE术中将TAH注入囊袋,应用裂隙灯活体检查和组织病理学检查方法观察术后后发性白内障形成情况和药物作
一、认识与探索随着改革、开放的进展,乡镇卫生院受到严重的冲击。由于国家对卫生经费的投入有限,卫生院退休职工逐年增加,加上卫生费用的上升,致使卫生院基补经费补偿机制
为探讨结肠康泰临床疗效的药理基础,观察了结肠康泰对小鼠正常及病理状态下小肠、结肠运动的影响。结果表明结肠康泰对正常小肠运动有一定促进作用,对结肠推进无明显影响;对病理
叶酸代谢酶的基因多态性与神经管畸形的关系赵如冰朱慧萍李竹(北京医科大学中国妇婴保健中心,北京100083)高同型半胱氨酸血症与神经管畸形(NTDs)的发生密切相关。导致同型半胱氨酸在体内蓄积
为探讨由黄芪、当归、川芎等补肾活血药组成的中药健胎液防治胎儿宫内发育迟缓的作用机理,本研究采用被动吸烟法建立胎儿宫内发育迟缓(IUGR)动物模型,运用蛋白质SDS—聚丙烯酰胺凝胶电泳
来源和背景:传统上讲DM(Direct Mail Advertising)是直邮广告的简称,即指将宣传品以指名的方式直接递送给最终消费者。这一源于美国的新兴广告形式已成为西方继电视、报纸后
刚果人民经过长期斗争,于今年6月30日从此利时殖民主义的奴役下实现独立。比利时政府不甘失败,竟在八天之后,即7月8日,以“保护”此利时侨民和“自由世界利益”为借口,派遣