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双异丙吡胺(Disopyramide)在体外降低动作电位O位相上升速率,并有膜稳定作用,在Vaughan Williams分类中归为第一类抗心律失常药.然而,本药对人体的电生理作用迄无定论.此乃因本药具有双重作用所使然.也就是说,本药兼有直接的膜抑制作用及与之相拮抗的抗胆碱能作用.本文报道在心脏移植患者(受者心脏的心房后部及窦房结残留于原位,仍受神经支配,供心则失去神经支配)评价双异丙吡胺的这两种作用方式.方法:8例原位心脏移植患者,在4～28个月的研究期间,未出现临床、生化或心电图的排异反
Disopyramide reduces the rate of rise of the action potential O phase in vitro and has membrane stabilizing effects and is classified as the first antiarrhythmic agent in the Vaughan Williams classification. However, the electrophysiological effects of this agent on the human body This is because the drug has a dual role, that is, the drug has both direct membrane inhibition and antagonism of the anticholinergic effect.This paper reports the heart transplant patients (recipients of the heart Atrial posterior and sino-atrial node remain in place, still subject to innervation, but for the loss of innervation) evaluation of these two modes of action of bispyribacide.Methods: 8 cases of orthotopic heart transplantation, at 4 ~ During the 28-month study, no clinical, biochemical, or ECG abnormalities were reported