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目的 探讨正常人和原发性开角型青光眼 (primaryopen angleglaucoma ,POAG)视网膜神经纤维层 (retinalnervefiberlayer,RNFL)的光学相干断层扫描 (opticalcoherencetomography ,OCT)图像特征 ,分析POAG患者RNFL厚度与正常人之间的差异 ,POAG患者RNFL与视野指数之间的关系。方法 采用OCT对 83例 (150眼 )正常人和 83例 (149眼 )POAG患者进行以视乳头中心为圆心 ,直径为 3 4 6mm的环形扫描 ,观察正常人和POAG患者OCT图像特征 ;将正常人和POAG患者各象限和平均RNFL厚度的均数进行比较 ,将各期POAG间RNFL厚度进行比较 ;将 115眼POAG的平均RNFL厚度与视野指数进行直线回归和相关分析 ;并分析了OCT检测POAG患者RNFL厚度的敏感性与特异性。结果 正常人RNFL的OCT图像特征为上下极厚 ,其次为颞侧 ,鼻侧最薄。曲线表现为双峰形。POAG患者的OCT图像可表现为局限性变薄或缺损、弥漫性变薄、弥漫性变薄并局限性缺损。正常人颞侧、上方、鼻侧、下方和平均RNFL厚度分别为 (90 1± 10 8) μm、(140 4± 10 5) μm、(85 2± 14 0 ) μm、(140 4± 9 7) μm和 (114 2± 6 0 )μm ,POAG患者相应的RNFL厚度分别为 (56 0± 31 0 ) μm、(81 0± 36 3) μm、(47 1± 2 7 5) μm、(73 4± 38 4 ) μm和(6 4 6± 2 8
Objective To investigate the characteristics of optical coherence tomography (OCT) images of normal and primaryopen angleglaucoma (POAG) retinal nerve fiber layer (RNFL), and to analyze the relationship between RNFL thickness and normal subjects The relationship between RNFL and visual field index in patients with POAG. Methods OCT images of 83 normal controls (POE) and 83 POAG patients (149 eyes) underwent OCT with a center of optic disc and a diameter of 346 mm. OCT images of normal and POAG patients were observed. The mean RNFL thickness of each POAG group was compared with the average RNFL thickness of POAG patients and POAG patients. The mean RNFL thickness of 115 POAGs was linearly correlated with the visual field index. Correlation analysis of POAG Sensitivity and specificity of patient RNFL thickness. Results The normal OCT images of RNFL were extremely thick, followed by the temporal side and the thinnest nasal side. The curve shows a bimodal shape. OCT images of patients with POAG may show localized thinning or defects, diffuse thinning, diffuse thinning, and localized defects. The mean temporal RNFL thickness of the normal subjects were (90 1 ± 10 8) μm, (140 4 ± 10 5) μm, (85 ± 14 0) μm, (140 4 ± 9 7) ) and (114 ± 60) μm, respectively. The corresponding RNFL thicknesses in POAG patients were 56 0 ± 31 0 μm, 81 0 ± 36 3 μm, 47 1 ± 2 7 5 μm, 4 ± 38 4) μm and (6 4 6 ± 2 8