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病人男 68岁农民因胸痛、发热、咳嗽1月,经抗炎对症治疗无效,于1989年10月12日来我科就诊,诊为浸润型肺结核痰菌阳性,以3HRS/9H_2R_2方案治疗。用药第3天,感上腹不适。第7天出现胃痛、恶心、呕吐。第8日晚10时突出现意识朦胧、烦躁、多言,言语不清,行动蹒跚,扑击样震颤。询问家属以往曾用INH、SM,均无不良反应,此次用RFP为第1次。故停RFP,改用3HES/9H_2E_2方案,并用镇静剂。第10日晚7时病人精神安定,神志转清经治疗观察数月未再出现类似现象。
68-year-old male patient suffering from chest pain, fever, cough January, anti-inflammatory symptomatic treatment ineffective, came to our department on October 12, 1989, was diagnosed as tuberculosis sputum positive tuberculosis, 3HRS / 9H_2R_2 regimen. On the third day of treatment, feeling of abdominal discomfort. Stomach pain, nausea and vomiting appeared on the 7th day. At 8 o’clock on the 8th prominence is now obscure, irritability, say more, slurred speech, action faltering, tremble like flutter. Family members in the past have used INH, SM, no adverse reactions, the use of RFP for the first time. Therefore, stop RFP, switch to 3HES / 9H_2E_2 program, and with tranquilizers. At 10 o’clock on the 10th night the patient’s mental stability, consciousness to clear the treatment for several months did not appear again after a similar phenomenon.