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目的评价局部晚期非小细胞肺癌(NSCLC)接受放化疗综合治疗的结果。方法 50例局部晚期非小细胞肺癌患者接受图像引导放疗联合NP方案化疗模式治疗。化学治疗方案采用NP方案(N:国产长春瑞滨,25 mg/m2,第1、8天使用;P:顺铂,25 mg/m2,第2～4天使用;28 d为1个周期),化疗从放疗开始第1天起同期应用,分别于第1、5周给予,放疗结束后巩固1个周期,共3个周期。图像引导放疗方法应用医科达Synergy医用直线加速器行图像引导放疗。中位放疗剂量62 Gy(55～69 Gy)。结果 50例患者完全缓解6例,部分缓解34例,稳定6例,进展4例,总有效率为80%。1年生存率为74%,4例(8%)患者出现NC I CTC≥3级放射性肺炎,16例(32%)患者出现放射性食管炎(Ⅰ～Ⅱ级)。结论图像引导放疗联合NP方案可获得较好的临床治疗效果,不良反应可以耐受。
Objective To evaluate the results of combined chemotherapy and radiotherapy in locally advanced non-small cell lung cancer (NSCLC). Methods Fifty patients with locally advanced non-small cell lung cancer underwent image-guided radiotherapy combined with NP regimen chemotherapy. Chemotherapy regimens used NP regimen (N: domestic vinorelbine, 25 mg / m2 on day 1 and 8; P: cisplatin 25 mg / m2 on days 2 and 4; 28 days on 1 cycle) , Chemotherapy from the first day of radiotherapy from the beginning of the same period of application, were given in the first 1,5 weeks, after the end of radiotherapy to consolidate 1 cycle, a total of 3 cycles. Image Guided Radiotherapy Methods Medical Radar Synergy Medical Linear Accelerator Line Guided Radiotherapy. The median dose of radiation was 62 Gy (55-69 Gy). Results In 50 cases, 6 cases were completely relieved, 34 cases partially relieved, 6 cases stabilized and 4 cases progressed. The total effective rate was 80%. The 1-year survival rate was 74%. In 4 (8%) patients, IICC≥3level pneumonitis occurred in 16 patients (32%), and esophagitis (Ⅰ ~ Ⅱlevel) occurred in 4 patients (8%). Conclusion Image guided radiotherapy combined with NP regimen can achieve better clinical effect and adverse reactions can be tolerated.