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目的 分析为首发老年抑郁症患者实施艾司西酞普兰合并支持性心理治疗的临床效果.方法 选择本院于2019年7月～2020年8月收治的68例诊断为首发抑郁症的老年患者,通过随机数字表法的方式将其进行分组,即对照组(34例,单独实施艾司西酞普兰治疗),观察组(34例,实施艾司西酞普兰合并支持性心理治疗),观察两组患者治疗后的总有效率以及不良反应发生率,同时对比两组患者治疗前、治疗2周以及治疗8周的汉密尔顿抑郁量表(HAMD)评分以及生活质量评分.结果 治疗前,观察组与对照组的HAMD评分以及生活质量评分相差不显著,均无统计学意义(P＞0.05).治疗后,观察组的治疗总有效率要高于对照组,同时观察组患者的不良反应发生率要低于对照组患者,差异均有统计学意义(P＜0.05);观察组患者治疗2周以及治疗8周的HAMD评分均低于对照组患者,同时观察组患者治疗2周以及治疗8周的生活质量评分均高于对照组患者,差异均有统计学意义(P＜0.05).结论 临床中在为首发老年抑郁症患者实施艾司西酞普兰药物治疗的同时,结合支持性心理治疗能够提升治疗效果,及时改善患者的抑郁程度,有利于提升患者的生活质量,并且这种治疗方式的安全性也比较高,可及时降低患者的不良反应发生率,具有较高的临床应用价值.“,”Objective To analyze the clinical effects of escitalopram combined with supportive psychotherapy for first-episode elderly depression patients. Methods A total of 68 elderly patients diagnosed with first-episode depression admitted to our hospital from July 2019 to August 2020 were selected and divided into groups by random number table. The control group (34 patients, escitalopram treatment alone), observation group (34 cases, escitalopram combined with supportive psychotherapy), to observe the total effective rate and the incidence of adverse reactions of the two groups of patients after treatment. At the same time, the Hamilton Depression Scale (HAMD) scores and quality of life scores of the two groups of patients before treatment, 2 weeks of treatment and 8 weeks of treatment were compared. Results Before treatment, the HAMD scores and quality of life scores of the observation group and the control group were not significantly different, and there was no statistical significance (P＞0.05). After treatment, the total effective rate of treatment in the observation group was higher than that in the control group, and the incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05); the observation group was treated for 2 weeks and 8 weeks of the HAMD scores were lower than those of the control group. At the same time, the quality of life scores of the observation group were higher than those of the control group for 2 weeks and 8 weeks of treatment, and the differences were statistically significant (P＜0.05). Conclusion In clinical practice, escitalopram drug treatment for first-episode elderly depression patients, combined with supportive psychotherapy can improve the therapeutic effect, improve the patient\'\'s depression in a timely manner, and help improve the quality of life of the patients, and the safety of the method is also relatively high, which can reduce the incidence of adverse reactions in patients in a timely manner, and has high clinical application value.