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目前药物剂型已发展为四大类型:第一类为一般剂型;第二类为缓释剂型和前体药物;第三类为控释制剂(第一代DDS制剂);第四类为靶向给药系统(第二代DDS制剂)。本文介绍辅料在缓释剂型、控释给药系统和靶向给药系统结构中的作用。1 缓释剂型 缓释制剂主要指应用药代动力学的原理,通过制剂工业学的方法选择适宜辅料合理设计剂型,以延缓药物从该剂型中的释放速率,使吸收徐缓,产生较平稳的血药浓度,以达到延长药物作用时间的一类剂型。
At present, the pharmaceutical dosage forms have been developed into four types: the first type is a general dosage form; the second type is a sustained-release dosage form and a prodrug; the third type is a controlled-release preparation (the first-generation DDS preparation); and the fourth type is a targeted one. Drug delivery system (second generation DDS formulation). This article describes the role of excipients in the formulation of sustained release dosage forms, controlled release drug delivery systems, and targeted drug delivery systems. 1 Sustained-release formulation Sustained-release formulation mainly refers to the principle of pharmacokinetics application. It selects suitable excipients to rationally design dosage forms through methods of formulation industry to delay the release rate of drug from the dosage form, so as to absorb slowly and produce more stable blood. Drug concentration to achieve a prolonged drug action time of a class of dosage forms.