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抗精神病药物对肝脏的毒性作用已屡有报导,但国内作长期对照观察的还较少,现将我们的观察结果报导如下,供参考。材料与方法对二个女病区连续住院六年以上、现仍住院、病史资料完整的123例进行统计分析。按有无服用抗精神病药物分为观察组和对照组。二组病者每年最少做一次肝功能检查(包括麝浊、锌浊、谷丙酶三项),连续观察五年以上,结合病史资料进行统计分析。病者所在的二个病区环境基本相同,均无传染性肝炎流行史。资料分析一、一般资料: 1.年龄:观察组72例,年龄25～67岁,平均45.3岁;对照组51例,年龄45～80岁,平均
The toxic effects of antipsychotics on the liver have been reported frequently, but the long-term comparative observation in China is still rare, and we report the following observations for reference. Materials and Methods Two female patients were hospitalized continuously for more than six years, and 123 cases with complete history data were analyzed statistically. According to the presence or absence of antipsychotic drugs were divided into observation group and control group. Two groups of patients do at least once a year liver function tests (including musk turbidity, zinc turbidity, three prothrombin), continuous observation of more than five years, combined with historical data for statistical analysis. The ward where the two wards environment is basically the same, no history of infectious hepatitis epidemic. Data Analysis First, the general information: 1. Age: observation group of 72 patients, aged 25 to 67 years, mean 45.3 years; control group of 51 patients, aged 45 to 80 years, mean