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目的 观察一氧化氮 (NO)、肿瘤坏死因子 -α(TNF-α)与乙肝后肝硬变 (PHC)患者病情变化的关系。方法 将 42例乙肝后肝硬变患者按 Child- Pugh分级法分成 A、B、C三组 ,检测各组患者血清 NO和 TNF-α水平 ,并以 2 0例健康献血员作为对照组。结果 PHC组血清 NO、TNF-α含量明显高于对照组 (P<0 .0 1) ,且按 A、B、C各组依次递增 ,各组间有显著性差异(P<0 .0 5 ) ,NO与 TNF-α呈直线正相关 (P<0 .0 1,r=0 .40 0 7)。结论 肝硬变时 NO和 TNF-α含量增加 ,与肝硬变病情进展有相关关系。
Objective To observe the relationship between the changes of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and cirrhosis of the liver (PHC). Methods 42 patients with posthepatitic cirrhosis were divided into A, B and C groups according to Child-Pugh grading method. Serum levels of NO and TNF-α were measured in each group, and 20 healthy blood donors were used as control group. Results The levels of serum NO and TNF-α in PHC group were significantly higher than those in control group (P <0.01), and increased in groups A, B and C with significant difference (P <0.05) ), There was a linear positive correlation between NO and TNF-α (P <0.01, r = 0.40 0 7). Conclusions The content of NO and TNF-α in liver cirrhosis increases, which is related to the progression of cirrhosis.