海洋环境污染物三丁基锡(tributyltin,TBT)引起的细胞内信号通路应答十分复杂,是一种集成式网络反应(integrated network-like intracellular response)。各种细胞因子及它们之间的作用关系构成类似集成电路样网络式分子反应,组成了细胞内一个个相对独立、又互相关联的反应模块。该文综述了TBT引起的细胞内信号通路转导的集成式网络反应现象,旨在为综合评价污染物危害性提供参考。 The intracellular signaling response caused by tributyltin (TBT), a marine environmental pollutant, is quite complex and is an integrated network-like intracellular response. A variety of cytokines and the relationship between them constitute a similar IC-like network of molecular reactions, composed of a relatively independent intracellular cells, and interrelated reaction modules. This review summarizes the integrated network reaction induced by TBT in the transduction of intracellular signaling pathways and aims to provide a reference for the comprehensive evaluation of the hazard of pollutants.