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[背景]砷是一个重要的全球环境健康问题。已有研究显示,生命早期砷暴露会导致婴儿期呼吸道感染发生率增加、儿童期肺功能下降、成年早期支气管扩张发生率增加。[目的]确定小鼠在生命早期的砷暴露是否会加剧其生命早期流感病毒感染的反应性。[方法]在宫内与整个产后生活中均使C57BL/6小鼠处于砷暴露状态。在1周龄时,令小鼠的一个亚组感染A型流感,然后评估砷暴露对病毒的清除、炎症、肺部结构和肺功能的急性和长期影响。[结果]生命早期的砷暴露使得小鼠对A型流感病毒的清除率下降、炎症反应加剧,并导致呼吸力学和气道结构的急性和长期性改变。[结论]在整个生命早期,砷暴露群体呼吸道感染的易感性增加合并炎症反应加剧可能会导致支气管扩张。
[Background] Arsenic is an important global environmental health issue. Studies have shown that early exposure to arsenic leads to an increased incidence of respiratory infections in infancy, decreased lung function in childhood, and an increased incidence of bronchiectasis in early adulthood. [Objective] To determine whether arsenic exposure in mice early in life can exacerbate the reactivity of influenza infection during early life. [Methods] C57BL / 6 mice were exposed to arsenic in both intrauterine and postnatal life. At 1 week of age, one subgroup of mice was infected with influenza A and the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function were assessed. [Results] Arsenic exposure in early life led to the decrease of mouse clearance rate of type A influenza virus, increased inflammatory reaction and the acute and long-term changes of respiratory mechanics and airway structure. [Conclusion] The increased susceptibility of respiratory tract infection in arsenic-exposed groups and the aggravation of inflammatory reaction may lead to bronchiectasis in early life.