目的研究神经生长抑制因子Nogo-A在新生大鼠神经系统中的分布特点,探讨Nogo-A与新生大鼠神经系统生长发育的关系,为其功能研究提供基础资料。方法以7日龄正常SD新生大鼠作为研究对象,采用免疫组化染色法观察Nogo-A蛋白在大脑、小脑、脊髓中的表达特点。结果在新生大鼠中枢神经系统中,Nogo-A蛋白的表达广泛,尤其在大脑皮质第三层、海马的前下托与胼胝体、小脑锥体细胞层、脊髓前后角表达较强。结论Nogo-A蛋白在中枢神经系统不同部位表达规律不同、强弱不等,其原因可能是Nogo-A表达于多种细胞,而且新生大鼠神经系统不同组织的再生能力不同。 Objective To investigate the distribution of Nogo-A in the nervous system of neonatal rats and to explore the relationship between Nogo-A and the growth and development of the nervous system of newborn rats and to provide basic information for its function study. Methods Normal SD neonatal rats of 7 days old were used as research objects. The expression of Nogo-A protein in brain, cerebellum and spinal cord was observed by immunohistochemistry. Results Nogo-A protein was widely expressed in the central nervous system of neonatal rats, especially in the third layer of the cerebral cortex. The anterior and inferior mandibular hippocampus and the corpus callosum, cerebellar pyramidal cell layers and spinal cord anterior and posterior horn were strongly expressed. Conclusion The expression of Nogo-A is different in different parts of the central nervous system. The reason may be that Nogo-A is expressed in many kinds of cells, and the regenerative capacity of different tissues in the nervous system of newborn rats is different.