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目的观察雾化吸入联合抗结核药物治疗肺结核合并支气管内膜结核的临床效果。方法选择2013年3月-2014年9月医院治疗的肺结核合并支气管内膜结核患者40例,随机分为观察组和对照组各20例。观察组予雾化吸入联合抗结核药治疗;对照组仅予抗结核药物治疗。观察2组在1个月、2个月、3个月时痰液中结核杆菌的转阴情况,并计算转阴率和治疗有效率。结果观察组在1个月、2个月、3个月后转阴人数及痰培养结核杆菌转阴率均高于对照组,且3个月后痰培养结核杆菌转阴率达到100.0%。2组比较差异有统计学意义(P<0.05)。3个月后,观察组总有效率100.0%明显高于对照组的70.0%,差异有统计学意义(P<0.05)。结论雾化吸入联合抗结核药治疗肺结核合并支气管内膜结核患者有效率高、痰菌转阴率高,值得临床推广应用。
Objective To observe the clinical effect of inhalation combined with anti-TB drugs in the treatment of pulmonary tuberculosis complicated with endobronchial tuberculosis. Methods Forty patients with pulmonary tuberculosis and endobronchial tuberculosis treated in our hospital from March 2013 to September 2014 were randomly divided into observation group (20 cases) and control group (20 cases). The observation group was treated with nebulized inhalation combined with anti-tuberculosis drugs; the control group was treated with anti-tuberculosis drugs only. Two groups were observed in 1 month, 2 months, 3 months sputum sputum mycobacterium negative conversion, and calculate the negative conversion rate and treatment efficiency. Results The number of negative people in the observation group at 1 month, 2 months and 3 months and the negative conversion rate of sputum culture Mycobacterium tuberculosis were higher than those in the control group. The negative conversion rate of sputum culture Mycobacterium tuberculosis reached 100.0% after 3 months. The difference between the two groups was statistically significant (P <0.05). After 3 months, the total effective rate in the observation group was 100.0%, which was significantly higher than that in the control group (70.0%, P <0.05). Conclusion The combination of nebulized inhalation and anti-tuberculosis drugs in the treatment of patients with pulmonary tuberculosis complicated with endobronchial tuberculosis is effective, and the sputum negative conversion rate is high, which is worthy of clinical application.