Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(Ⅲ) ions

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Lanthanide elements(Ln)play an important role in industry and agriculture.As a result of the increasing consumption of lanthanides,environmental emission of Ln has become detrimental to the health of flora and fauna.Current methods for trace lanthanides detection mainly rely on sophisticated instruments.In this article,a Ln~(3+)dependent DNAzyme was incorporated into a hydrogel to generate Ln~(3+)sensitive DNAzyme hydrogel for portable colorimetric detection.The enzyme strand and its substrate strand act as crosslinker and functional unit of the hydrogel with polyacrylamide chains as the scaffold and gold nanoparticles(AuNPs)as the indicator of hydrogel stability.Any ions in the Ln~(3+)series can trigger the cleavage of substrate strand by activating the enzyme strand,thereby decreasing the crosslink ratio and leading to collapse of the hydrogel.The release of the encapsulated AuNPs turns the supernatant wine red.Using this colorimetric method,Ln~(3+)can be detected with high sensitivity,with a limit of detection(LOD)of 20 nM for Ce~(3+).The hydrogel responds specifically to any Ln~(3+)ion and works well with the spiked lake sample without the need of instruments and skilled operators.Our results suggest that the lanthanide responsive hydrogel can be used for portable and sensitive detection of Ln~(3+)contamination in the field. Lanthanide elements (Ln) play an important role in industry and agriculture. As a result of the increasing consumption of lanthanides, environmental emission of Ln has become detrimental to the health of flora and fauna. Current methods for trace lanthanides detection mainly rely on sophisticated instruments .In this article, a Ln ~ (3+) dependent DNAzyme was incorporated into a hydrogel to generate Ln ~ (3+) sensitive DNAzyme hydrogel for portable colorimetric detection. The enzyme strand and its substrate strand act as a crosslinker and functional unit of the hydrogel with polyacrylamide chains as the scaffold and gold nanoparticles (AuNPs) as the indicator of hydrogel stability. All ions in the Ln ~ (3 +) series can trigger the cleavage of substrate strand by activating the enzyme strand, thereby decreasing the crosslink ratio and leading to collapse of the hydrogel. The release of the encapsulated AuNPs turns the supernatant wine red. Using this colorimetric method, Ln ~ (3+) can be detected with high sensitivi ty, with a limit of detection (LOD) of 20 nM for Ce ~ (3 +). The hydrogel responds specifically to any Ln ~ (3+) ion and works well with the spiked lake sample without the need of instruments and skilled operators .Our results suggest that the lanthanide responsive hydrogel can be used for portable and sensitive detection of Ln ~ (3+) contamination in the field.
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