在皮肤型红斑狼疮中趋化因子受体CCR4及其配体胸腺和活化调节趋化因子/CCL17对淋巴细胞的趋化作用

来源 :世界核心医学期刊文摘(皮肤病学分册) | 被引量 : 0次 | 上传用户:wyk3601
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Skin-infiltrating T lymphocytes are thought to play a major role in the pathogenesis of cutaneous lupus erythematosus (CLE). In this study, we investigated the role of the chemokine receptor 4 (CCR4) and its ligand thymus-and activation-regulated chemokine (TARC/CCL17) for the recruitment of T cells in inflamed skin of patients with CLE. We found significant numbers of CCR4+T lymphocytes in the skin of all patients with CLE. Interestingly, a subset of patients with disseminated scarring skin involvement were characterized by both lesional and circulating CD8+T cells expressing CCR4. Destruction of epidermal and adnexal structures was histomorphologically associated with CCR4+cytotoxic T cells invading basal layers of the epidermis where keratinocytes showed apoptotic death. The CCR4 ligand TARC/CCL17 was strongly expressed in skin lesions and elevated in the serum of CLE patients. The functional relevance of lymphocytic CCR4 expression could be confirmed by TARC/CCL17-specific in vitro migration assays. Our investigations suggest that CCR4 and TARC/CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8+T cells expressing CCR4 appear to be involved in scarring subtypes of CLE. Skin-infiltrating T lymphocytes are thought to play a major role in the pathogenesis of cutaneous lupus erythematosus (CLE). In this study, we investigated the role of the chemokine receptor 4 (CCR4) and its ligand thymus-and activation-regulated chemokine ( TARC / CCL17) for the recruitment of T cells in inflamed skin of patients with CLE. We found significant numbers of CCR4 + T lymphocytes in the skin of all patients with CLE. Interestingly, a subset of patients with disseminated scarring skin involvement were characterized by Both lesional and circulating CD8 + T cells expressing CCR4. Destruction of epidermal and adnexal structures was histomorphologically associated with CCR4 + cytotoxic T cells invading basal layers of the epidermis where keratinocytes showed apoptotic death. The CCR4 ligand TARC / CCL17 was strongly expressed in skin lesions and elevated in the serum of CLE patients. The functional relevance of lymphocytic CCR4 expression could be confirmed by TARC / CCL17-specific in vitro migration assays. Our investigations suggest that CCR4 and TARC / CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8 + T cells expressing CCR4 appear to be involved in scarring subtypes of CLE.
其他文献
深海里,谁是人们最青睐的打捞工?什么动物即使柔弱无骨却能在紧急逃命的关口将无骨的“脚”变成逃命的飞毛腿?深海里什么动物为了吃到食物而会开动脑筋使用工具呢?这就是本文
山东省宁阳县第二小学在活动中重视在“小”字上做文章,从而达到引领少先队员成长的目的。“小记者”采访“大人物”侯秀荣,“安全中国十佳矿嫂”。她几十年如一日在矿井门口
在班级管理中,后进生是最令人伤脑筋的,但是又是我们必须解决的问题。我们该怎样对待后进生呢?有的教师歧视那些调皮的纪律差的学生,认为他们不可救药。不去从思想上很好地教
2007年2月11日,中国国家旅游局局长邵琪伟、世界旅游组织代表郑重宣布大连荣获“中国最佳旅游城市”称号。在本次创佳过程中,大连市提出“举全市之力,创建中国最佳旅游城市”
奥迪在日内瓦车展上发布了全新一代TT车型,与其前两任先辈们比起来,全新TT无论外形还是内饰设计都一反常态地走起了男性化路线。前两任TT的造型设计都有点儿背离奥迪整体家族
“滴水之恩,当以涌泉相报。”这是中国的传统美德,我们中国人自古以来对这一人性中的良知就有深刻的理解,也把它当做人立于天地间最基本的素质。感恩是学会做人的支点,感恩之
美联社目前报道说,一项新的研究认为,感染在导致早产方面所起的作用可能大于医生的估计。这项研究发现,每7名早产妇女中就有一人的羊水中含有细菌或病毒。这一研究的规模较小
【摘要】当前对小学生进行心理健康教育如今已成为社会的共识,成为素质教育的重要组成部分,把语文学科教学作为切入口,在语文学科教育过程中渗透对学生进行心理健康教育是有其必然性,也是很必要的、合理的。本文主要阐述如何在平时的教学中运用各种手段,潜移默化的对学生进行心理健康教育,让学生形成正确的人生观和价值观。  【关键词】张扬个性 自我教育语感 渗透健康人格  【中图分类号】G423 【文献标识码】A
根据升力法设计轴流式水力机械转轮叶片的基本原理、方法和步骤,设计了贯流式水轮机叶片,建立了贯流式水轮机的三维模型,并基于Fluent,采用RNGκ-ε双方程湍流模型和SIMPLEC
随着军队院校教育改革的深化,信息素养这一教育概念被越来越多的人接受,信息素养是军校大学生综合素质的重要组成部分。在现代信息化战争的条件下,重视学生信息素养的培养,已