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目的提高肾嫌色细胞癌的诊治水平。方法回顾性分析4例肾嫌色细胞癌患者的临床资料。男3例,女1例,年龄34-76岁,平均52岁。结果3例患者行肾癌根治术,1例行肾部分切除术。术后病理诊断为肾嫌色细胞癌,病理分期:pT1aNxM01例,pT1bN0M03例。病理分级:G13例,G21例。免疫组织化学染色:CK8(低分子量细胞角蛋白)阳性,Vimentin(波型蛋白)阴性,Hale胶体铁阳性。随访4个月至8年,平均4年。4例患者均健在,无肿瘤复发或转移。结论肾嫌色细胞癌是一种低度恶性的肾细胞癌,影像学检查对其诊断有重要帮助,确诊有赖于组织病理学检查,手术治疗后预后较好。
Objective To improve the diagnosis and treatment of chromophobe renal cell carcinoma. Methods Retrospective analysis of 4 cases of renal cell carcinoma in patients with clinical data. 3 males and 1 females, aged 34-76 years, mean 52 years old. Results Three patients underwent radical nephrectomy and one underwent partial nephrectomy. Postoperative pathological diagnosis of chromophobe renal cell carcinoma, pathological stage: pT1aNxM01 cases, pT1bN0M03 cases. Pathological grade: G13 cases, G21 cases. Immunohistochemical staining: Positive CK8 (low molecular weight cytokeratin), negative Vimentin (wave protein), and positive Hale colloid iron. Followed up for 4 months to 8 years, an average of 4 years. All 4 patients were alive without tumor recurrence or metastasis. Conclusions Kidney chromophobe cell carcinoma is a kind of low grade renal cell carcinoma. Radiographic examination is very helpful to its diagnosis. The diagnosis depends on the histopathological examination, and the prognosis is good after the surgical treatment.