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蛋白酪氨酸激酶作为抗肿瘤药物的靶点,在肿瘤的治疗中具有重要意义。天然产物中蛋白酪氨酸激酶抑制剂的寻找越来越受关注。就近年来文献报道的天然产物中蛋白酪氨酸激酶抑制剂按其结构类型加以综述,其结构类型包括酚类、醌类、生物碱、甾醇等,其中酚类数量较多,尤其是含有多个羟基的芳环加一个侧链的化合物,同时,一些比较有特点的海洋类化合物也显示了较好活性。
Protein tyrosine kinase as a target of anti-tumor drugs in the treatment of tumors of great significance. The search for protein tyrosine kinase inhibitors in natural products is gaining more and more attention. In recent years, reports of natural products in the literature of protein tyrosine kinase inhibitors according to their type of structure are reviewed, the structure types include phenols, quinones, alkaloids, sterols, etc., of which phenols more, especially containing more Hydroxy aromatic ring plus a side chain compounds, at the same time, some of the more characteristic marine compounds also showed good activity.