牙髓干细胞(DPSCs)具有免疫调节性能,但其潜在机制仍未完全明了。本研究中,我们发现DPSCs具有在体外诱导激活T细胞凋亡的能力,体内注射至小鼠结肠炎模型,可改善炎症相关的组织损伤。从机制上讲,DPSCs诱导的免疫调节与Fas配体(FasL)的表达有关,该配体是一种跨膜蛋白,在诱导Fas凋亡通路中起着重要作用。采用siRNA下调DPSCs中FasL的表达,可降低DPSCs在体外诱导T细 Dental pulp stem cells (DPSCs) have immunomodulatory properties, but the underlying mechanisms are still not fully understood. In this study, we found that DPSCs have the ability to induce T-cell activation in vitro and that injection into mouse colitis models in vivo can improve inflammation-related tissue damage. Mechanistically, immune regulation induced by DPSCs is related to the expression of Fas ligand (FasL), a transmembrane protein that plays an important role in the induction of Fas apoptosis. Using siRNA to down-regulate the expression of FasL in DPSCs can reduce the in vitro induction of T-cells by DPSCs