论文部分内容阅读
目的：探讨ＨＢＶ与其它肝炎病毒重叠感染对肝炎患者病情及预后的影响。方法：分析比较了单独ＨＢＶ、ＨＢＶ与ＨＡＶ、ＨＢＶ与ＨＣＶ、ＨＢＶ与ＨＤＶ及ＨＢＶ与ＨＥＶ重叠感染者的临床表现、肝功能、重型肝炎发生频率及其预后。结果：ＨＢＶ与ＨＣＶ和ＨＢＶ与ＨＤＶ重叠感染者发生重型肝炎的频率分别为４４．４％和４０．０％，均显著高于单独ＨＢＶ感染者（２３．１％）；ＨＢＶ与ＨＡＶ和ＨＢＶ与ＨＥＶ重叠感染者发生重型肝炎的频率分别为２２．５％和２０．０％，与单独ＨＢＶ感染者相差不显著。与单独ＨＢＶ感染者相比，ＨＢＶ与ＨＣＶ、ＨＤＶ重叠感染所致重肝患者的血清总胆红素和病死率均显著升高，其凝血酶原活动度则更低；ＨＢＶ与ＨＣＶ、ＨＤＶ重叠感染所致慢性肝炎患者血清总胆红素显著升高、持续时间更长；ＨＢＶ与ＨＡＶ、ＨＥＶ重叠感染所致慢性肝炎、重型肝炎患者血清总胆红素均显著升高，但重肝病死率、凝血酶原活动度及其肝功能异常时间差别均不显著。结论：ＨＢＶ与ＨＣＶ、ＨＤＶ重叠感染能加重肝炎患者的肝损害，重叠感染所致重肝患者的病情更重，病死率更高。ＨＢＶ与ＨＡＶ、ＨＥＶ重叠感染，在一定程度上能加重肝炎患者病情，但不会加剧肝炎患者发生急性肝功能衰竭，对其?
Objective: To investigate the influence of HBV and other hepatitis viruses on the condition and prognosis of hepatitis patients. Methods: The clinical manifestations, hepatic function, incidence and severity of severe hepatitis in HBV infected with HAV, HBV, HCV, HBV and HDV and HBV and HEV were compared and analyzed. Results: The frequency of severe hepatitis was 44.4% and 40.0% respectively in patients infected with HBV, HCV and HDV, and significantly higher than those in HBV infected patients (23.1%). HBV, HAV and HBV The incidence of severe hepatitis in HEV overlap patients was 22.5% and 20.0% respectively, which was not significantly different from those in HBV-infected patients. The serum total bilirubin and case fatality rate were significantly higher in patients with severe liver caused by overlapping infection of HBV and HCV and HDV, and the activity of prothrombin was lower than that in HBV infected patients. HBV and HCV, HDV overlap Serum total bilirubin in patients with chronic hepatitis caused by infection significantly increased for a longer duration; serum total bilirubin was significantly higher in patients with chronic hepatitis and severe hepatitis due to overlapping infection with HBV, HAV and HEV, but the case-fatality rate , Prothrombin activity and liver dysfunction time differences were not significant. Conclusion: Over-infection of HBV, HCV and HDV can aggravate liver damage in patients with hepatitis. Patients with severe hepatitis caused by overlapping infection have more serious illness and higher mortality. HBV and HAV, HEV overlapping infection, to a certain extent, aggravate the condition of hepatitis patients, but will not exacerbate hepatitis patients with acute liver failure, its?