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前文指出,三唑并噻二唑类化合物之所以显示出广谱生物活性,无疑起因于其基本骨架。但核上取代基位置及结构的影响又是不可忽视的,深入研究很有必要。考虑烷基以及芳氧亚甲基醚能增加分子脂溶性及负电性,有可
The foregoing indicates that the reason why the triazolothiadiazoles show broad spectrum biological activity undoubtedly stems from their basic framework. However, the influence of the position and structure of the nucleus on the nucleus can not be neglected. Therefore, further study is necessary. Considering the alkyl and aryloxymethylene ether can increase the molecular fat-soluble and negative electricity, may