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长期以来国内治疗流行性脑脊髓膜炎(流脑)首选磺胺药。随着磺胺药的耐药菌株逐渐增多,许多医院已经倾向于首选青霉素,其疗效甚佳,至今国内还未见有耐药性的报道。近期我院传染科收治一例经脑脊液培养证实的流脑患者,药敏试验对青霉素有耐药性,临床应用青霉素治疗亦无效。因此病例罕见,故报道如下。患儿汤某,男,5月龄。因发热伴呕吐一天,于1989年7月11日入本院儿科。一天前患儿发热伴一次非喷射状呕吐,稀便两次,时有惊厥,嗜睡。脑脊液常规:外观无色浑浊,潘氏试验(+++),细胞数1440×10~6/L,
For a long time the domestic treatment of epidemic cerebrospinal meningitis (meningitis) preferred sulfa drugs. With the sulfa drug-resistant strains gradually increased, many hospitals have preferred penicillin, its efficacy is very good, so far no domestic drug resistance has been reported. Recently, our hospital infectious diseases admitted to a case of cerebrospinal fluid culture confirmed by patients with meningitis, drug sensitivity test for penicillin resistance, clinical application of penicillin treatment is ineffective. Therefore rare cases, it is reported as follows. Children with a soup, male, 5 months old. Due to fever with vomiting one day, July 11, 1989 into our hospital pediatrics. One day before the fever in children with a non-jet-like vomiting, loose stool twice, when convulsions, lethargy. Cerebrospinal fluid routine: the appearance of colorless turbidity, Pan test (+++), the number of cells 1440 × 10 ~ 6 / L,