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目的:探讨大豆异黄酮与维生素C、维生素E的协同作用对2型糖尿病患者血脂代谢的影响。 方法:将120例符合研究条件的2型糖尿病患者随机分为糖尿病非干预组、低剂量组、中间剂量组和高剂量组,与30例正常人对照。分别检测口服葡萄糖耐量试验(OGTY)时0,1,2,4,6h血液中三酰甘油、胆固醇、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low densitylipoprotein cholesterol,LDL-C)、载脂蛋白A1(apolipoprotein A1,ApoA1)、载脂蛋白B(apohpoprotein B,ApoB)的动态变化。 结果:OGTT后,正常对照组各项血脂指标与空腹比较均无显著性变化。4个糖尿病组中非干预组餐1,2 h后的三酰甘油显著高于0 h(F=5.05,4.52,P<0.05);餐后6h总胆固醇显著高于0,1h(F=3.86,3.91,P<0.05);餐后4,6hLDL-C显著高于0 h(F=4.34,6.28,P<0.05);餐后6hApoB显著高于正常对照组(F=4.31,P<0.05)和高剂量组(F=3.99,P=0.046)。低剂量组餐后1,2 h的三酰甘油显著高于Oh(F=4.51,4.46,P<0.05);餐后6h LDL-C显著高于0 h(F=5.38,P<0.05);餐后6 hApoB显著高于正常对照组(F=4.29,P<0.05)和高剂量组(F=3.87,P<0.05)。而中剂量组和高剂量组则呈剂量依赖性表现出降低三酰甘油、胆固醇、LDL-C,ApoB和升高HDL-C,ApoA1,ApoA
Objective: To investigate the synergistic effects of soy isoflavones and vitamin C and vitamin E on blood lipid metabolism in type 2 diabetic patients. Methods: A total of 120 type 2 diabetic patients who were eligible for the study were randomly divided into diabetic non-intervention group, low-dose group, middle-dose group and high-dose group, and 30 normal subjects. The blood levels of triglyceride, cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (low density lipoprotein cholesterol) and low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) in patients with diabetes mellitus. Results: After OGTT, there was no significant difference between the fasting blood glucose and fasting blood in the normal control group. The triglycerides in the non-intervention group were higher than those in the non-intervention group for 1 and 2 hours (P0.05 and P <0.05), and the total cholesterol in the non-intervention group was significantly higher than 0 and 1h , 3.91, P <0.05) .LDL-C at 4 and 6h after meal was significantly higher than that at 0h (F = 4.34,6.28, P <0.05); ApoB at 6h after meal was significantly higher than that of the normal control group And high dose group (F = 3.99, P = 0.046). The triglycerides at 1 and 2 h after meal in low dose group were significantly higher than those in Oh (F = 4.51 and 4.46, P <0.05). LDL-C at 6 h after meal was significantly higher than that at 0 h (F = 5.38 and P <0.05) The level of ApoB at 6 h after meal was significantly higher than that of the normal control group (F = 4.29, P <0.05) and high dose group (F = 3.87, P <0.05). However, the dose-dependent decrease of triglyceride, cholesterol, LDL-C, ApoB and HDL-C, ApoA1, ApoA