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为探讨高渗氯化钠羟乙基淀粉40注射液(Hypertonic Sodium chloride Hydroxyethyl starch 40 injection,HSH)对小肠 粘膜核因子-K appa B(NF-κB)的影响,以SD大鼠为实验对象,分别检测休克前,重度休克后以及以HSH和林格氏 液复苏后不同时间点小肠粘膜NF-κB表达情况。结果显示失血后小肠粘膜内炎细胞浸润增加,并出现糜烂和溃疡,小 肠粘膜内炎症细胞和腺细胞NF-κB的表达明显增加,给予HSH复苏后,小肠粘膜形态明显改善,表达NF-κB的细胞恢 复至休克前水平,给予林格氏液复苏组小肠粘膜损伤进一步加重,NF-κB的表达进一步增加。结论:失血性休克发生后, 小肠组织中NF-κB的表达迅速增强,其表达程度与炎性细胞的浸润程度及损伤程度一致,RL复苏可增强肠道组织中NF- κB的表达。HSH能快速抑制肠道组织中NF-κB的表达。
To investigate the effect of Hypertonic Sodium Chloride Hydroxyethyl starch 40 Injection (HSH) on NF-κB in small intestine mucosa, SD rats were used as experimental subjects, The expression of NF-κB in small intestine mucosa was measured before shock, after severe shock, and after resuscitation with HSH and Ringer’s solution respectively. The results showed that inflammatory cells and glandular cells NF-κB expression in intestinal mucosa increased after hemorrhagic inflammatory cell infiltration and erosion and ulceration occurred. After HSH resuscitation, the morphological changes of small intestinal mucosa were significantly improved. The cells expressing NF-κB Recovery to pre-shock level, given Ringer’s solution group of intestinal mucosa injury further aggravated, NF-κB expression was further increased. Conclusion: After hemorrhagic shock, the expression of NF-κB in small intestine rapidly increases. The expression of NF-κB is consistent with the degree of infiltration and injury of inflammatory cells. RL resuscitation can enhance the expression of NF-κB in intestinal tissue. HSH can rapidly inhibit the expression of NF-κB in intestinal tissue.