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目的:DKK-1在宫颈鳞癌中的表达情况。方法:采用免疫组化SABC法检测宫颈癌中DKK-1的表达。结果:DKK-1阳性表达定位于胞浆中,在慢性宫颈炎、CINⅠ、CINⅡ-Ⅲ、宫颈鳞癌中阳性表达率依次降低,四组比较差异有显著性(P<0.05)。结论:在鳞状上皮恶性转化的过程中,随着病变程度的增加,DKK-1阳性表达率逐渐降低,提示DKK-1可能在宫颈鳞癌的发生过程中起一定作用。
Objective: The expression of DKK-1 in cervical squamous cell carcinoma. Methods: Immunohistochemical SABC method was used to detect the expression of DKK-1 in cervical cancer. Results: The positive expression of DKK-1 localized in the cytoplasm. The positive rates of DKK-1 in chronic cervicitis, CINⅠ, CINⅡ-Ⅲ and cervical squamous cell carcinoma were decreased in turn. There was significant difference between the four groups (P <0.05). Conclusion: In the process of malignant transformation of squamous epithelium, the positive expression rate of DKK-1 gradually decreases with the increase of the degree of lesions, suggesting that DKK-1 may play a role in the occurrence of cervical squamous cell carcinoma.