论文部分内容阅读
以依地酸二钠钙（Ｃａ—ＥＤＴＡ）为对照，观察了４—甲氧苄基Ｄ—葡糖胺—Ｎ—二硫代羧酸钠（ＭｅＯＢＧＤＴＣ）对染镉大鼠尿镉及尿锌、铜、铁、锰等微量元素的促排作用。给大鼠腹腔注射４．４４８μｍｏｌＣｄ（２＋）ｋｇ（－１）日（－１）的氯化镉，共４周。然后分别投以８８９．６００μｍｏｌｋｇ（－１）日（－１）的Ｃａ—ＥＤＴＡ和ＭｅＯＢＧＤＴＣ，共５次。结果表明：Ｃａ—ＥＤＴＡ和ＭｅＯＢＧＤＴＣ均能显著增加大鼠的尿镉水平，并可持续至第５给药日，分别达单纯染镉组的１．４６～３．４５倍和１．４０～３．３３倍；Ｃａ－ＥＤＴＡ还能明显增加大鼠尿锌、锰及铁的排泄，而ＭｅＯＢＧＤＴＣ对此则无明显影响。
The effects of 4-methoxybenzyl D-glucosamine-N-dithiocarboxylate sodium (MeOBGDTC) on urinary cadmium and urinary zinc of cadmium-exposed rats were observed using calcium disilicate (Ca-EDTA) , Copper, iron, manganese and other trace elements of the role of promoting emissions. Rats were intraperitoneally injected with 4.448 μmol Cd (2+) kg (-1) day (-1) cadmium chloride for 4 weeks. Then, 889.600μmolkg (-1) day (-1) Ca-EDTA and MeOBGDTC were respectively cast for 5 times. The results showed that both Ca-EDTA and MeOBGDTC significantly increased urinary cadmium levels in rats and could last for the fifth administration day, reaching 1.46 ~ 3.45 times and 1.40 ~ 3 .33-fold; Ca-EDTA also significantly increased urinary zinc, manganese and iron excretion in rats, while MeOBGDTC no significant effect on this.