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左旋多巴疗法在60年代后期得以广泛应用时,曾希望能用该药永久性控制震颤麻痹。但十多年临床经验说明:虽然约80％的病人在左旋多巴治疗的头3年效果良好,但最终几乎所有病人都产生了无法解决的问题。其中有些是该病的发展所致,而另一些则可能是左旋多巴本身引起的。因此,目前神经生物学家正对左旋多巴疗法重作评价,并在寻找能纠正震颤麻痹症状而又无左旋多巴样副作用的药物。多巴胺是一种递质,震颤麻痹患者由于脑中产生多巴胺的某些神经细胞发生退行性变而缺乏这种递质,以致神经冲动传递中断而引起症状,其主要症状是自主运动起动困难、运动
L-dopa therapy was widely used in the late 1960s when it was hoped that the drug could be used to permanently control paralysis. However, more than a decade of clinical experience has shown that although nearly 80% of patients are effective in the first 3 years of levodopa treatment, almost all patients eventually have unresolved problems. Some are caused by the development of the disease, while others may be caused by levodopa itself. Therefore, current neurobiologists are reevaluating levodopa therapy and looking for drugs that can correct the symptoms of Parkinsonism without levodopa-like side effects. Dopamine is a neurotransmitter, paralysis patients due to degeneration of certain nerve cells in the brain degeneration occurs and lack of such neurotransmitters, resulting in disruption of nerve impulse transmission and cause symptoms, the main symptoms are difficult to start autonomous movement, exercise