Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety range,broad-spectrum and multi-targets,etc.Therefore,traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer.Studies about applying traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below. Multi-drug resistance (MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma. Comparing with western reversal agents, traditional Chinese medicine have advantages of low cost, hypotoxicity, wide safety range, broad-spectrum and multi-targets, etc. , traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer .Studies about adopting traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below.