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人γ干扰素具有抗病毒、抗肿瘤及免疫调节活性.成熟的 IFN-γ由143个氨基酸组成.C端长度参差不齐,但不影响生物学活性;如果去掉 C 端13个氨基酸,其抗病毒活性只有原来的千分之一.我们的工作证明 IFN-γ从 N 端至 C 端的132个氨基酸为其生物学活性的基本结构.在许多癌细胞表面,上皮生长因子(EGF)受体明显增多.其配体除了 EGF 外,还包括了转化生长因子(TGF),痘苗病毒的生长因子(VGF)等.这类 EGF 样多肽具有类似的分
Human interferon gamma has anti-viral, anti-tumor and immunomodulatory activity.The matured IFN-γ consists of 143 amino acids with uneven length on the C-terminus, but does not affect the biological activity. If the C-terminal 13 amino acids are removed, The virus activity is only one in 1000. Our work demonstrated that the 132 amino acids of IFN-γ from N-terminal to C-terminal are the basic structures of its biological activity.On the surface of many cancer cells, the receptor of epidermal growth factor (EGF) And its ligands include, in addition to EGF, transforming growth factor (TGF), vaccinia virus growth factor (VGF), etc. Such EGF-like polypeptides have similar scores