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目的了解成都市健康人群流脑Y群及W135群抗体水平,为制定全市防制流脑措施提供科学依据。方法对成都市<1岁、1~2岁、3~4岁、5~6岁、7~14岁、15~19和≥20岁7个年龄组,每组随机抽取不少于30人,采集血清。采用ELISA法检测人群血清中的Y群和W135流脑抗体,并进行统计分析。结果人群Y群的抗体阳性率及几何平均浓度(GMC)为88.28%、5.57μg/ml,W135群的抗体阳性率及GMC为61.64%、2.79μg/ml。流脑Y群以1~2岁组抗体阳性率最高、<1岁最低,GMC<1岁组最高、7~14岁最低,W135群以<1岁组抗体阳性率最高、5~6岁最低。结论成都市健康人群的Y群和W135群抗体阳性水平及GMC较低,应重视和加强流脑Y群和W135群疫苗接种工作,以预防Y群和W135群脑膜炎奈瑟菌引起的流行性脑膜炎。
Objective To understand the levels of antibodies against human brain Y and W135 in healthy population in Chengdu and provide a scientific basis for the prevention and control of meningococcal disease in Chengdu. Methods Seven age groups of <1 year old, 1 ~ 2 years old, 3 ~ 4 years old, 5 ~ 6 years old, 7 ~ 14 years old, 15 ~ 19 years old and ≥ 20 years old in Chengdu were randomly selected. Collect serum. The Y population and W135 meningococcal antibody in the serum were detected by ELISA and analyzed statistically. Results The antibody positive rate and geometric mean concentration (GMC) of population Y were 88.28% and 5.57μg / ml, respectively. The antibody positive rate and GMC of W135 were 61.64% and 2.79μg / ml respectively. The antibody positive rate was highest in group 1 ~ 2 years old, the lowest in 1 year old group, the highest in GMC <1 year old group, the lowest in 7 ~ 14 years old group, the highest positive rate of antibody in W135 group <1 year old group and the lowest in 5 ~ 6 years old group . CONCLUSIONS: The antibody positive levels of Y and W135 and the low GMC of healthy population in Chengdu are relatively low. Vaccination should be emphasized and strengthened in group Y and group W135 in order to prevent the epidemic caused by Neisseria meningitides in group Y and group W135 meningitis.