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H_2受体拮抗剂代表药物甲氰咪胍,国内于1979年首先由重庆合成。临床治疗胃、十二指肠溃疡获得良效。近年来国外在这方面又有新的进展。现本文就H_2受体的建立、作用机理以及新型的H_2受体拮抗剂,作综述。一、组织胺受体的确立自从发现安替根和新安替根后,这类抗组织胺药如苯海拉明、扑尔敏等不断补充,对变态反应例如过敏性鼻炎、荨麻疹、枯草热和昆虫叮咬等病,疗效卓著。人们将这类药称为经典的抗组织胺药。不久发现,它们虽然能对抗组织胺的多种效应,但不能阻止
H 2 receptor antagonist on behalf of the drug cimetidine, domestic first synthesized in 1979 by Chongqing. Clinical treatment of stomach, duodenal ulcer obtained good effect. In recent years, foreign countries have made new progress in this regard. In this paper, the establishment of H 2 receptors, the mechanism of action and a new type of H 2 receptor antagonists are reviewed. First, the establishment of histamine receptors Since the discovery of antipyrine and the new antipyrine, such antihistamines such as diphenhydramine, chlorpheniramine and other constantly added, the allergic reactions such as allergic rhinitis, urticaria, hay Heat and insect bites and other diseases, the effect is remarkable. People call these drugs classically antihistamines. It was soon discovered that although they were able to combat the multiple effects of histamine, they could not be stopped