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NLR(nucleotide binding domain and leucine-rich-repeat-containing proteins)分子的功能是近年来免疫学研究的热点,该分子的功能不仅限于免疫识别,而且广泛参与免疫反应的调节,特别是炎症反应的调节。病毒或者细菌感染过程中,机体依赖模式识别受体触发固有免疫反应。目前已发现的有3类模式识别受体—Toll样受体(Toll-like receptors,TLR)、RIG-I样受体(RIG-I-like receptors,RLR)、NLR。病原体相关模式分子(pathogen associated molecular patterns,PAMP)同模式识别受体结合后,会引起IRF3和(或)NF-κB的活化,进而促进抗病毒和促炎细胞因子的产生,如
The function of NLR (nucleotide binding domain and leucine-rich-repeat-containing proteins) is a hot research topic in immunology in recent years. The function of this molecule is not limited to immune recognition. It is widely involved in the regulation of immune responses, especially the regulation of inflammatory responses . During virus or bacterial infection, the body relies on pattern recognition receptors to trigger an innate immune response. There are three types of pattern recognition receptors Toll-like receptors (TLRs), RIG-I-like receptors (RLRs) and NLRs. Pathogen associated molecular patterns (PAMPs), when combined with pattern recognition receptors, cause the activation of IRF3 and / or NF-κB, thereby promoting the production of anti-viral and proinflammatory cytokines such as