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目的：分析１１２例异位妊娠（活胚）采用甲氨蝶呤（ＭＴＸ）化疗效果及影响疗效的因素。方法：１１２例异位妊娠均采用ＭＴＸ肌注２０ｍｇ，每日一次，连续５天化疗。每周两次监测血β－ｈｃＧ值及Ｂ超，直至正常。结果：化疗有效，同时并用我所治疗宫外孕的中药促进异位妊娠包块吸收治愈１０６例，占９４．６％。余６例失败转手术。经逐步回归分析表明：治疗效果与化疗前患者的孕龄的长短、血β－ｈｃＧ值的高低、是否有胎心及阴道出血量、注射ＭＴＸ后副反应出现率有关；而与患者的年龄、异位妊娠包块的大小及治疗前腹痛发生率无统计学意义。结论：ＭＴＸ是目前对异位妊娠较为安全，有效的化疗药物。
Objective: To analyze the effect of methotrexate (MTX) chemotherapy in 112 cases of ectopic pregnancy (live embryo) and the factors affecting the curative effect. Methods: 112 cases of ectopic pregnancy were treated with MTX intramuscular injection of 20mg once daily for 5 consecutive days of chemotherapy. Blood β-hcG and B-ultrasound were monitored twice weekly until normal. Results: Chemotherapy was effective. At the same time, 106 cases of ectopic pregnancy were cured with traditional Chinese medicine which was treated by ectopic pregnancy, accounting for 94.6%. More than 6 cases failed surgery. The stepwise regression analysis showed that the effect of treatment was related to the length of gestational age, the level of β-hcG, fetal heart rate and vaginal bleeding, the incidence of side effects after injection of MTX, but not with age, Ectopic pregnancy mass size and the incidence of abdominal pain before treatment was not statistically significant. Conclusion: MTX is currently a safe and effective chemotherapy for ectopic pregnancy.