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1例40岁男性患者,因患高血压服用卡托普利片6.25 mg,3次/d;1周后剂量增至12.5 mg,3次/d。1个月后患者TBil由13.6μmol/L升至37.3μmol/L。停用卡托普利1周后复查,TBil 28.7μmol/L,1个月后TBil为15.6μmol/L。经检测血、尿常规正常,肝炎病毒学标志物阴性,考虑胆红素升高和卡托普利有关。之后,卡托普利改为硝苯地平缓释片,未再出现上述症状。
One 40-year-old male patient took captopril tablets 6.25 mg, 3 times daily for hypertension and a dose 12.5 mg three times daily after 1 week. The patient’s TBil rose from 13.6 μmol / L to 37.3 μmol / L after 1 month. One week after the discontinuation of captopril, a review of TBil 28.7 μmol / L and one month later TBil was 15.6 μmol / L. After testing the blood, urine normal, hepatitis virology markers negative, consider bilirubin and captopril related. After that, captopril was changed to nifedipine sustained-release tablets and the above symptoms did not recur.