论文部分内容阅读
目的探讨脑型脂肪酸结合蛋白(B-FABP)在急性脑梗死(ACI)发病过程中的动态变化及临床意义。方法采用ELISA检测100例ACI患者发病l d内、第7d和第l4d内的血清B-FABP,分析其与梗死部位、大小及神经功能缺损的关系。结果 100例脑梗死患者发病l d内、第7d和第l4d血清B-FABP含量水平均明显高于对照组(P<0.01),其中在急性期(发病1d内)B-FABP敏感性达68%;腔隙性梗死组B-FABP水平明显高于其它三组(P<0.01),全前循环梗死组的B-FABP水平高于后循环梗死组与部分前循环梗死组(P<0.05),后循环梗死组高于部分前循环梗死组(P<0.05);B-FABP水平在小病灶梗死组高于大病灶梗死组、中病灶组(P<0.01),而大病灶梗死组高于中病灶组(P<0.05);B-FABP水平在轻型组高于重型组、中型组(P<0.01);重型组高于中型组(P<0.05)。结论 ACI患者血清中B-FABP水平变化与梗死部位、大小和病情严重程度有关,其高敏感性可作为早期诊断脑梗死的潜在、快速的生物学指标。
Objective To investigate the dynamic changes and clinical significance of brain-derived fatty acid binding protein (B-FABP) in the pathogenesis of acute cerebral infarction (ACI). Methods The serum levels of B-FABP in 100 cases of ACI patients on the first day, the 7th day and the 14th day were detected by ELISA. The relationship between the B-FABP and the infarct size, size and neurological deficits was analyzed. Results The levels of B-FABP in serum of 100 patients with cerebral infarction within 1d, 7d and 14d were significantly higher than those of control group (P <0.01), and the sensitivity of B-FABP in acute phase (within 1d) ; The level of B-FABP in lacunar infarction group was significantly higher than that in the other three groups (P <0.01). The B-FABP level in all anterior circulation infarction group was higher than that in posterior circulation infarction group and partial anterior circulation infarction group (P <0.05) The posterior circulation infarction group was higher than that of some anterior circulation infarction group (P <0.05). The level of B-FABP was higher in small infarction group than in large infarction group and middle lesion group (P <0.01) (P <0.05). The level of B-FABP in the light group was higher than that in the heavy group and the medium group (P <0.01), that in the heavy group was higher than that in the medium group (P <0.05). Conclusion The serum level of B-FABP in patients with ACI is related to the location, size and severity of the disease. Its high sensitivity can be used as a potential and rapid biological indicator for early diagnosis of cerebral infarction.