论文部分内容阅读
一32岁男子用甲腈咪胍(cimetidine)1000mg/日治疗十二指肠溃疡6周(1979年6月1日至7月10日)。7月初患者发觉头发脱落并逐渐加重。7月末,胡须呈小块圆形脱落。9月末,发现体毛脱落,以小腿最明显。性欲和性能力无明显改变。10月初次求治。基础的激素测定表明血浆睾丸酮水平低,黄体化激素和滤泡刺激素水平高(见表),催乳激素和其他激素水平没有异常。头颅 X 片检查表明蝶鞍正常,精液分析正常(1979年11月)。核染色体组型为46,XY。肌电图和常规实验室检查正常。通过体外淋巴细胞转化试验研究了细胞免疫功能。在补充自体血清的大培养(macroculture)中,甲腈
A 32-year-old man treated duodenal ulcer with cimetidine 1000 mg / day for 6 weeks (June 1 to July 10, 1979). At the beginning of July, the patient found the hair shedding and gradually increased. At the end of July, beard was small rounded off. The end of September, found that body hair loss, the most obvious leg. No significant change in libido and sexual ability. The first time in October for treatment. The basal hormone tests showed low plasma testosterone levels, high levels of luteinizing hormone and follicle stimulating hormone (see table), no abnormalities in prolactin and other hormone levels. X-ray examination of the skull showed normal semen, semen analysis was normal (November 1979). Nuclear chromosome type 46, XY. Electromyography and routine laboratory tests are normal. Cellular immune function was studied by in vitro lymphocyte transformation assay. In macroculture supplemented with autologous serum, carbonitrile