本文报告了４例原发性脑恶性淋巴瘤，男３例，女１例，平均年龄３３岁。４例病人均经开颅手术，１例行肿瘤部分切除，３例行完全切除。所有病例均经病理学证实。术后行放射治疗。其中２例发生肺转移，１例发生脊髓转移（Ｌ１～２）。作者结合文献讨论了本病的组织学起源，病因，临床特点、诊断、治疗和预后。 This article reports 4 cases of primary malignant lymphoma of the brain, 3 males and 1 females, with an average age of 33 years. Four patients underwent craniotomy, one was partially resected and the other three were completely resected. All cases were pathologically confirmed. Radiotherapy after surgery. Two of them developed lung metastases and one had spinal cord metastases (L1 ~ 2). The authors discussed the histological origin, etiology, clinical features, diagnosis, treatment and prognosis of the disease in combination with the literature.