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_(ppp)A_(2’p),’A_(2’p,)’A(2’-5’P_3A_3) activates macrophages and increases the phagocytosis of macrophages from different species including human beings. This indicates that the activation of macrophages may be a general action of 2’-5’P_3A_3. This discovery broadens the effect of 2’-5’P_3A_3 beyond the antiviral field.α-Feto-protein (AFP) inhibits the phagocytosis of macrophages and may be involved in the development of hepatoma. Data presented here show that 2’-5’P_3A_3 can antagonize this suppressive effect of AFP.Methods used so far for introducing 2’-5’P_3A_3 into the cells were made with the aid of CaCl_2, etc. under conditions which may not be the same as those used clinically. It was found that 2’-5’P_3A_3 can develop its biological effect without the aid of CaCl_2, etc.
(2’p,) ’A (2’-5’P_3A_3) activates macrophages and increases the phagocytosis of macrophages from different species including human beings. This indication that the activation of macrophages may be a general action of 2’-5’P_3A_3. This discovery broadens the effect of 2’-5’P_3A_3 beyond the antiviral field. α-Feto-protein (AFP) inhibits the phagocytosis of macrophages and may be involved in the development of hepatoma. Data presented here show that 2’-5’P_3A_3 can antagonize this suppressive effect of AFP. Methods used so far for introducing 2’-5’P_3A_3 into the cells were made with the aid of CaCl_2, etc. under conditions which may not be the same as those used clinically. It was found that 2’-5’P_3A_3 can develop its biological effect without the aid of CaCl_2, etc.