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目的:了解我院药品不良反应(ADR)发生的特点及一般规律,为临床合理用药提供参考。方法:统计我院2007～2009年上报的154例ADR报告中患者的基本情况,以及涉及药物品种、给药途径、临床表现等。结果:药品不良反应报告中女性构成比略高于男性,50岁以上患者发生ADR比例较高;引起ADR最常见的药物为抗肿瘤药和免疫调节药,其次为中药制剂;累及的器官-系统以皮肤及附件损害最为常见,其次为全身性损害和心血管系统损害。结论:应及时准确地ADR监测上报、分析评价信息回馈临床,以预防和减少ADR的发生,保证药物治疗的安全有效。
Objective: To understand the characteristics and general rules of adverse drug reaction (ADR) in our hospital and to provide reference for clinical rational drug use. Methods: The basic situation of 154 cases of ADR reported in our hospital from 2007 to 2009 were statistically analyzed, as well as the variety of drug involved, route of administration, clinical manifestations and so on. Results: The ADRs in ADRs were slightly higher than those in men, and ADRs were higher in patients over 50 years old. The most common ADR-causing drugs were anti-tumor drugs and immunomodulatory drugs, followed by traditional Chinese medicine preparations. The organ-system involved Damage to the skin and accessories is most common, followed by generalized and cardiovascular damage. Conclusion: The ADR monitoring should be timely and accurately reported, and the information feedback should be analyzed and evaluated in order to prevent and reduce the occurrence of ADR and ensure the safe and effective drug treatment.