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目的研究促肝细胞生长素(pHGF)联合丹参注射液治疗急性黄疸型病毒性肝炎的治疗效果。方法按“病毒性肝炎防治方案”选择患者,随机分配为治疗组和对照组,研究过程中密切观察患者的血液流变学指标。结果治疗组症状、体征消失时间和肝功能恢复正常时间明显短于对照组(P<0.05),血浆粘度等血液流变学指标明显改善(P<0.05),转成重型肝炎病例明显减少(P<0.05),两组比较有显著性差异。结论促肝细胞生长素具有降低丙氨酸氨基转移酶、刺激肝细胞再生、促进蛋白质合成、减少蛋白质分解、恢复肝细胞的功能。丹参注射液有抗炎、抗氧自由基,改善微循环,稳定及保护肝细胞和胆管上皮细胞的作用。采用促肝细胞生长素联合丹参注射液治疗急性黄疸型病毒性肝炎疗效可靠,未发现不良反应。
Objective To study the therapeutic effect of hepatocyte growth-promoting factor (pHGF) combined with Salvia miltiorrhiza injection on acute jaundice-type viral hepatitis. Methods According to the “viral hepatitis prevention and treatment program” select the patients were randomly assigned to the treatment group and control group, the study was closely observed in patients with hemorheological parameters. Results The symptoms, the disappearance of signs and the normal time of liver function recovery in the treatment group were significantly shorter than those in the control group (P <0.05). The indexes of hemorheology such as plasma viscosity were significantly improved (P <0.05) <0.05), there was a significant difference between the two groups. Conclusions Hepatocyte growth-promoting factor (Hcy) has the functions of reducing alanine aminotransferase, stimulating hepatocyte regeneration, promoting protein synthesis, reducing protein breakdown and restoring hepatocytes. Salvia injection has anti-inflammatory, antioxidant free radicals, improve microcirculation, stability and protection of liver cells and bile duct epithelial cells. The use of hepatocyte growth-promoting hormone combined with Salvia injection in the treatment of acute jaundice virus hepatitis is reliable and no adverse reactions have been found.