本文列举50余种药物(详见表1.2.3)的致畸作用(包括致畸时间,临床意义及畸胎特点等项),并对药物的致畸机制进行探讨。药物的致畸作用:畸胎是指药物在并不损害母体的情况下却能干扰胚胎和胎儿的发育,导致功能、生化和结构方面的异常。药物致畸的最大危险性出现于临界期(器官分化期),临界期对药物最敏感,是致畸的敏 This article lists more than 50 kinds of drugs (see Table 1.2.3) teratogenic effects (including teratogenic time, clinical significance and teratogenic characteristics, etc.), and the teratogenic mechanism of the drug are discussed. Teratogenic effects of drugs: teratogenic means that the drug can interfere with the development of the fetus and fetus without impairing the mother’s body, resulting in functional, biochemical and structural abnormalities. The greatest risk of teratogenic drugs appear in the critical period (organ differentiation), the critical phase of the drug is the most sensitive, is teratogenic sensitivity