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目的观察子痫前期患者外周血中辅助性T淋巴细胞1(Th1)、辅助性T淋巴细胞2(Th2)、Th1/Th2比率与超敏C反应蛋白(hs-CRP)水平的变化,探讨其变化与子痫前期发生、发展的关系。方法采用流式细胞技术检测63例子痫前期患者(轻度35例,重度28例)和45例正常妊娠孕妇外周血中Th1、Th2、Th1/Th2比率,同时检测其hs-CRP水平。结果 1子痫前期组Th1、Th1/Th2比率、hs-CRP水平均高于正常妊娠组(P<0.05),其中重度组Th1、Th1/Th2比率、hs-CRP水平明显高于轻度组(P<0.01)。2Th1/Th2比率与hs-CRP呈正相关(r=0.72,P=0.025),且随病情的严重程度呈上升趋势。结论子痫前期患者体内Th1/Th2比率处于失衡状态,联合检测Th1/Th2比率与hs-CRP水平,可用于评价子痫前期病情的严重程度。
Objective To observe the changes of peripheral blood T lymphocyte 1 (Th1), T helper 2 (Th2), Th1 / Th2 and hs-CRP in patients with preeclampsia Changes and the occurrence and development of preeclampsia. Methods Flow cytometry was used to detect the Th1, Th2, Th1 / Th2 ratios in 63 preeclampsia patients (35 mild cases and 28 severe cases) and the levels of hs-CRP in peripheral blood of 45 normal pregnant women. Results 1 The levels of Th1, Th1 / Th2 and hs-CRP in preeclampsia group were higher than those in normal pregnancy group (P <0.05), and the levels of Th1, Th1 / Th2 and hs-CRP in severe group were significantly higher than those in mild group P <0.01). The 2Th1 / Th2 ratio was positively correlated with hs-CRP (r = 0.72, P = 0.025), and it was increased with the severity of the disease. Conclusion The Th1 / Th2 ratio in patients with preeclampsia is in an imbalanced state. The combined detection of Th1 / Th2 ratio and hs-CRP level can be used to evaluate the severity of preeclampsia.