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许多学者从事关于乙型肝炎病毒(HBV)参与肝损伤的机理的研究,发现肝组织内HBV抗原的含量与肝脏损伤的严重程度之间存在着反比关系。从而提示,HBV本身不能使肝细胞损伤,可能是宿主的免疫反应参与感染肝细胞HBV的清除,因此导致肝脏损伤。不管肝细胞坏死最初过程如何,终究还是以肝细胞浆破坏而确定。基于这一结果,有关肝细胞表面抗原特性的研究以及肝细胞膜的改变,对造成免疫学反应的组织损伤所起的作用的研究,是目前乙型肝炎免疫病理研究中的一个重要课题。肝细胞抗原近年来,研究了两种与乙型肝炎有关的肝脏抗原。一、肝特异性指蛋白(LSP)1972年
Many scholars engaged in the study on the mechanism of hepatitis B virus (HBV) involvement in liver injury and found that there is an inverse relationship between the level of HBV antigen in liver tissue and the severity of liver damage. Thus, HBV itself can not damage liver cells, which may be the host’s immune response involved in the clearance of HBV infected liver cells, resulting in liver damage. Regardless of the initial process of hepatocyte necrosis, after all, or to determine the destruction of liver cell plasma. Based on these results, the research on the characteristics of hepatocyte surface antigen and the change of hepatocyte membrane, which play an important role in the immunological pathology of hepatitis B, is the research on the role of tissue damage caused by immunological reaction. Hepatocyte Antigen In recent years, two liver antigens related to Hepatitis B have been studied. First, the liver-specific protein (LSP) 1972