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目的探讨有氧运动对高脂膳食大鼠血液中胃促生长素(Ghrelin)和血脂的影响。方法成年SD大鼠30只,分为3组,每组10只,分为正常对照组、高脂对照组、高脂运动组,建立运动高脂膳食动物模型。对各组大鼠血液中血糖、甘油三酯(’IG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)进行测试;使用酶免试剂盒测试Ghrelin。结果高脂膳食组大鼠体重为(405.7±28.9)g,血糖为(9.38±3.66)mol/L,TC为(2.992±0.086)mol/L,TG为(0.585±0.055)mol/L,LDL-C为(0.325±0.073)mol/L,均高于正常对照组;血液中Ghrelin含量为(1 153.38±323.25)pg/mm3,HDL-C为(0.388±0.073)mol/L,均低于正常对照组,且差异有统计学意义(P﹤0.01)。有氧运动后,体重为(366.9±31.3)g),血糖为(7.53±0.12)mol/L,TC为(1.898±0.141)mol/L,TG为(0.543±0.043)mol/L,LDL-C为(0.287±0.022)mol/L均明显降低;血液中Ghrelin含量为(1 398.34±325.56)pg/mm3,HDL-C为(0.495±0.069)mol/L,均明显升高,差异有统计学意义(P﹤0.01)。结论有氧运动能减少大鼠体内脂肪组织含量,升高大鼠血液中Ghrelin的含量,降低TC含量,升高HDL含量,为运动治疗高脂血症(AS)提供试验依据。
Objective To investigate the effects of aerobic exercise on blood ghrelin and blood lipids in high fat diet rats. Methods Thirty adult Sprague-Dawley rats were randomly divided into three groups (n = 10): normal control group, high-fat control group and high-fat exercise group. Animal models of exercise-induced high fat diet were established. Blood glucose, triglyceride (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured in the blood of each group. Box test Ghrelin. Results The body weight of rats in high fat diet group was (405.7 ± 28.9) g and the blood glucose was (9.38 ± 3.66) mol / L, TC was (2.992 ± 0.086) mol / L and TG was (0.585 ± 0.055) C was (0.325 ± 0.073) mol / L, both of which were higher than that of the normal control group. The Ghrelin level in the blood was (1 153.38 ± 323.25) pg / mm3 and the HDL-C was 0.388 ± 0.073 mol / L, Normal control group, and the difference was statistically significant (P <0.01). The body weight was (366.9 ± 31.3) g after aerobic exercise, the blood glucose was (7.53 ± 0.12) mol / L, TC was (1.898 ± 0.141) mol / L and TG was (0.543 ± 0.043) C was (0.287 ± 0.022) mol / L, the level of Ghrelin in blood was (1 398.34 ± 325.56) pg / mm3 and HDL-C was (0.495 ± 0.069) mol / L, Significance (P <0.01). Conclusion Aerobic exercise can reduce the content of adipose tissue in rats, increase the content of Ghrelin, decrease the content of TC and increase the content of HDL in rat blood, and provide experimental basis for the exercise therapy of hyperlipidemia (AS).