在美国,青光眼是失明的主要原因,青光眼是指一组具有共同特征的疾病:视神经萎缩和视觉范围缩小,通常眼内压升高,如果不治疗可造成不可逆转的失明,这种情况的直接原因是眼房水没有完全排除。最近,唯一可接受的青光眼治疗方法是降低升高的眼内压。已采用几种方法治疗升高的眼内压,肾上腺素能药物和胆碱能药物,二者均用于治疗,其副作用与此类药物的副作用有关。已知其它物质通过不同的方式降低眼内压,如从毛喉鞘蕊花 Coleus forskohlli 植物根中提取的一种二萜毛喉鞘蕊花素(forskolin),以及从大 In the United States, glaucoma is a major cause of blindness. Glaucoma refers to a group of diseases that have common characteristics: optic atrophy and diminished visual range, usually elevated intraocular pressure, and direct treatment if untreated can result in irreversible blindness The reason is that aqueous humor is not completely ruled out. Recently, the only acceptable treatment for glaucoma is to reduce elevated intraocular pressure. Several methods have been used to treat elevated intraocular pressure, adrenergic and cholinergic drugs, both of which are used for treatment and whose side effects are associated with the side effects of such drugs. Other agents are known to reduce intraocular pressure in a variety of ways, such as forskolin, a diterpenoid hair from the root of Coleus forskohlli,