Pancreatic cancer has an overall 5-year survival rate of less than 5%.Unfortunately,patient survival has not substantially improved in the last couple of decades despite advances in treatment modalities that have been successful in other cancer types.The poor response of pancreatic cancer to therapy is a majo obstacle faced by clinicians.Increasing attention is bein paid to how tumor cells and non-tumor cells influenc each other in the pancreatic tumor microenvironment Tumor-associated macrophages(TAMs)are a highligh in this field because of their vast presence in th tumor microenvironment.TAMs promote angiogenesis metastasis,and suppress the anti-tumor immun response.Here we review the current understandin of the role of TAMs in regulating the progression o pancreatic cancer. Pancreatic cancer has an overall 5-year survival rate of less than 5% .Unfortunately, patient survival has not substantially improved in the last couple of zillion for advances in other cancerous types. The poor response of pancreatic cancer to therapy is a majo obstacle faced by clinicians. Increasing attention is bein paid to how tumor cells and non-tumor cells influenc each other in the pancreatic tumor microenvironment Tumor-associated macrophages (TAMs) are a highligh in this field because of their substantial in th tumor microenvironment. TAMs promote angiogenesis metastasis, and suppress the anti-tumor immun response. Here we review the current understandin of the role of TAMs in regulating the progression of pancreatic cancer.