已有报道,苯巴比妥直肠给药的生物利用度约为89%,其钠盐直肠给药比口服给药作用更快、更有效。因而直肠给药,在儿科尤受重视。然而Leucuta 等却提出相反意见,认为苯巴比妥栓剂的生物利用度比口服低,可能是由于药物在水中难溶解而引起的。本文研究直肠给药后,因苯巴比妥和苯巴比妥钠的溶解度不同以 It has been reported that the bioavailability of phenobarbital for rectal administration is about 89%, and its sodium rectal administration is faster and more effective than oral administration. Therefore, rectal administration, especially in pediatrics. Leucuta et al., However, put forward the opposite view, arguing that the lower bioavailability of phenobarbital suppository than oral solution may be due to the poor solubility of the drug in water. This study of rectal administration, due to the solubility of phenobarbital and phenobarbital sodium to different