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目的：探讨某院维吾尔族心胸外科手术患者医院感染发病率及影响因素。方法回顾性查阅新疆喀什地区某医院心胸外科2010年6月—2014年6月收治的维吾尔族患者病历，记录相关临床资料，调查其术后医院感染发病率，并采用单因素及多因素 logistic 回归模型分析患者术后医院感染的影响因素。结果共收集779例维吾尔族患者资料，术后发生医院感染53例，医院感染发病率为6．80％。不同感染部位感染发病率由高至低依次为下呼吸道（2．44％），消化道（1．28％）、泌尿道（1．16％）、上呼吸道（1．03％）和手术部位（0．51％）。多因素 logistic回归分析结果显示，糖尿病史、身体质量指数（BMI）≥30 kg／m2、手术时间≥160 min 和侵入性操作是维吾尔族心胸外科手术患者医院感染的危险因素。结论该院维吾尔族心胸外科手术患者医院感染发病率较高，主要危险因素有糖尿病史、BMI 高、手术时间长和侵入性操作。“,”Objective To evaluate the incidence and influencing factors for post-operative healthcare-associated in-fection(HAI)in Uyghur patients undergoing cardiothoracic surgery in a hospital.Methods Clinical data of Uyghur patients hospitalized in the department of cardiothoracic surgery in a hospital of Kashgar region between June 2010 and June 2014 were collected,incidence of post-operative HAI was surveyed.Influencing factors for post-operative HAI were analyzed by univariate and multivariate logistic regression models.Results A total of 779 patients’clini-cal data were collected,53 patients (6.80%)developed post-operative HAI.The major infection sites were lower respiratory tract (2.44%),digestive tract(1 .28%),urinary tract(1 .16%),upper respiratory tract(1 .03%),and surgical sites(0.51 %).Multivariate logistic regression analysis showed that history of diabetes,body mass index (BMI)≥30 kg/m2 ,duration of operation ≥ 160 minutes,and invasive procedure were risk factors for post-opera-tive HAI in Uyghur patients undergoing cardiothoracic surgery.Conclusion Incidence of post-operative HAI in Uy-ghur patients undergoing cardiothoracic surgery in this hospital is high,risk factors for HAI are history of diabetes, high BMI,long duration of operation,and invasive procedure.